Glucosephosphate dehydrogenase deficiency and malaria. J Mol Med. Reduced prevalence of Plasmodium falciparum infection and of concomitant anaemia in pregnant women with heterozygous G6PD deficiency. Trop Med Int Health. WHO Working Group. Glucosephosphate dehydrogenase deficiency. Bull World Health Organ.
Glucose 6 phosphate dehydrogenase deficiency. Mason PJ. New insights into G6PD deficiency. Br J Haematol. Beutler E. G6PD deficiency. Red cell enzymopathies.
In: Hoffman R, ed. Hematology: basic principles and practice. Philadelphia: Churchill Livingstone, — Glucosephosphate dehyrdogenase deficiency. Rapid epidemiologic assessment of glucosephosphate dehydrogenase deficiency in malaria-endemic areas in Southeast Asia using a novel diagnostic kit.
A rapid single-step screening method for glucosephosphate dehydrogenase deficiency in field applications. Japanese Journal of Tropical Medicine and Hygiene. Semiquantitative screening test for G6PD deficiency detects severe deficiency but misses a substantial proportion of partially-deficient females. Glucosephosphate dehydrogenase deficiency neonatal screening: preliminary evidence that a high percentage of partially deficient female neonates are missed during routine screening.
J Med Screen. A practical approach to the evaluation of the anemic child. Pediatr Clin North Am. Glucosephosphate dehydrogenase; G6PD. Acute hemolysis and severe neonatal hyper-bilirubinemia in glucosephosphate dehydrogenase-deficient heterozygotes.
J Pediatr. Favism in a female newborn infant whose mother ingested fava beans before delivery. Differential diagnosis and management of anemia in the newborn. Contribution of haemolysis to jaundice in Sephardic Jewish glucosephosphate dehydrogenase deficient neonates. Role of hemolysis in neonatal jaundice associated with glucosephosphate dehydrogenase deficiency.
Conjugated bilirubin in neonates with glucosephospate dehydrogenase deficiency. Edwards CQ. Anemia and the liver. Hepatobiliary manifestations of anemia. Clin Liver Dis. Diagnosis and management of hyperbilirubinemia in the term neonate: for a safer first week. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia.
Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation [published correction appears in Pediatrics ;]. Valaes T. Fractionation of serum bilirubin conjugates in the exploration of the pathogenesis of significant neonatal bilirubinemia associated with glucosephosphate dehydrogenase deficiency.
Kaplan M, Abramov A. Neonatal hyperbilirubinemia associated with glucosephosphate dehydrogenase deficiency in Sephardic-Jewish neonates: incidence, severity, and the effect of phototherapy. Glucosephosphate dehydrogenase deficiency and carboxyhemoglobin concentrations associated with bilirubin-related morbidity and death in Nigerian infants. Favism is when someone has a very severe reaction to fava beans broad beans. They are at risk of acute haemolysis, in which their red blood cells break down faster than the body can replace them.
This can be life-threatening. Some people with favism are even at risk when exposed to pollen from the fava plant. People with favism are always G6PD-deficient, but not all people with G6PD deficiency react this strongly to fava beans.
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Illustrated Textbook of Paediatrics. Michel M. Autoimmune and intravascular hemolytic anemias. Goldman-Cecil Medicine. Review provided by VeriMed Healthcare Network. Editorial team. Glucosephosphate dehydrogenase deficiency.
Red blood cell destruction can be triggered by infections, certain foods such as fava beans , and certain medicines, including: Antimalarial medicines such as quinine Aspirin high doses Nonsteroidal anti-inflammatory drugs NSAIDs Quinidine Sulfa drugs Antibiotics such as quinolones, nitrofurantoin Other chemicals, such as those in mothballs, can also trigger an episode.
You are more likely to develop this condition if you: Are African American Are of Middle Eastern decent, particularly Kurdish or Sephardic Jewish Are male Have a family history of the deficiency A form of this disorder is common in whites of Mediterranean descent. Symptoms are more common in men and may include: Dark urine Fever Pain in abdomen Enlarged spleen and liver Fatigue Pallor Rapid heart rate Shortness of breath Yellow skin color jaundice.
Exams and Tests. A blood test can be done to check the level of G6PD. So you could be exposed to the chemical by inhaling the vapor or ingesting products that contain it. Henna is a popular dye used for temporary tattoos and hair dye. There are reported cases of henna triggering hemolytic crises in people with G6PD deficiency. Newborns under the age of 2 months are especially sensitive to this reaction.
Did you know that favism is another term for G6PD deficiency, especially in severe cases? Fava beans also known as broad beans can trigger a hemolytic attack if you have G6PD deficiency. Some people recommend removing all legumes such as beans, peas, lentils, or peanuts from your diet. G6PD is an inherited form of hemolytic anemia that can cause damage to your red blood cells. Many people with G6PD deficiency don't experience any symptoms at all on a daily basis. That said, there are some medications and foods you should avoid if you have this condition.
Certain antibiotic, anti-inflammatory, and anti-malarial medications can trigger red blood cell breakdown. Likewise, fava beans have a similar reaction and are best to avoid as well. Having G6PD deficiency doesn't mean you can't take any medications. Still, you should know common medications to avoid to prevent damage to your red blood cells. This is not a complete list of items you should avoid if you have G6PD deficiency.
There are other medications that only cause red cell breakdown if taken in high doses. Others only trigger problems in specific types of G6PD deficiency. They can let you know whether the medications are safe to take with G6PD deficiency.
Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. National Library of Medicine. Glucosephosphate dehydrogenase deficiency. Updated September 15, Nemours KidsHealth. G6PD deficiency. Updated July
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